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Multicentre comparison of quantitative PCR-based assays to detect SARS-CoV-2, Germany, March 2020

: Muenchhoff, M.; Mairhofer, H.; Nitschko, H.; Grzimek-Koschewa, N.; Hoffmann, D.; Berger, A.; Rabenau, H.; Widera, M.; Ackermann, N.; Konrad, R.; Zange, S.; Graf, A.; Krebs, S.; Blum, H.; Sing, A.; Liebl, B.; Wölfel, R.; Ciesek, S.; Drosten, C.; Protzer, U.; Boehm, S.; Keppler, O.T.

Fulltext ()

Eurosurveillance 25 (2020), No.24, Art. 2001057, 5 pp.
ISSN: 1560-7917
ISSN: 1025-496X
Journal Article, Electronic Publication
Fraunhofer IME ()

Containment strategies and clinical management of coronavirus disease (COVID-19) patients during the current pandemic depend on reliable diagnostic PCR assays for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we compare 11 different RT-PCR test systems used in seven diagnostic laboratories in Germany in March 2020. While most assays performed well, we identified detection problems in a commonly used assay that may have resulted in false-negative test results during the first weeks of the pandemic.