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2019
Journal Article
Titel
Current State of Bone Adhesives - Necessities and Hurdles
Abstract
The vision of gluing two bone fragments with biodegradable and biocompatible adhesives remains highly fascinating and attractive to orthopedic surgeons. Possibly shorter operation times, better stabilization, lower infection rates, and unnecessary removal make this approach very appealing. After 30 years of research in this field, the first adhesive systems are now appearing in scientific reports that may fulfill the comprehensive requirements of bioadhesives for bone. For a successful introduction into clinical application, special requirements of the musculoskeletal system, challenges in the production of a bone adhesive, as well as regulatory hurdles still need to be overcome. In this article, we will give an overview of existing synthetic polymers, biomimetic, and bio-based adhesive approaches, review the regulatory hurdles they face, and discuss perspectives of how bone adhesives could be efficiently introduced into clinical application, including legal regulations.
Author(s)
Böker, Kai O.
Department of Trauma Surgery, Orthopaedics and Plastic Surgery, University Medical Center Goettingen
Jäckle, Katharina
Department of Trauma Surgery, Orthopaedics and Plastic Surgery, University Medical Center Goettingen
Taheri, Shahed
Department of Trauma Surgery, Orthopaedics and Plastic Surgery, University Medical Center Goettingen
Grunwald, Ingo
Industrial and Environmental Biology, Hochschule Bremen-City University of Applied Sciences
Byern, Janek von
Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Austrian Cluster for Tissue Regeneration, Faculty of Life Science, University of Vienna, Core Facility Cell Imaging and Ultrastructure Research
Schilling, Arndt F.
Department of Trauma Surgery, Orthopaedics and Plastic Surgery, University Medical Center Goettingen