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  4. Nonirritant and Cytocompatible Tinospora cordifolia Nanoparticles for Topical Antioxidant Treatments
 
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2020
Journal Article
Title

Nonirritant and Cytocompatible Tinospora cordifolia Nanoparticles for Topical Antioxidant Treatments

Abstract
Tinospora cordifolia extract contains antioxidants such as polyphenols, and thus, it has been used as a natural phytochemical antioxidant therapeutic agent. Many of these compounds are insoluble or only partially soluble in water. In this study, we produced a novel aqueous nanoparticle formulation, with an average particle size of 182.9 ± 3.8 nm, to improve the dispersion of the bioactive compounds in water and to increment its bioavailability. The nanoparticles are composed of polyphenols, alkaloids, and glycosides. We studied the effect of this nanoparticle formulation on mouse 3T3 fibroblast cell viability and New Zealand rabbit dermal irritability tests. Concentrations of 2.5, 25, and 250 µg/mL resulted in similar cell viability to cells in culture media. An intermediate concentration of 12.45 mg/ml was used for the acute dermal irritability test. There were no severe alterations that compromised animal health. These results represent a precedent for application of such nanoparticles derived from plant stems, such as Tinospora cordifolia, in biomedicine and in antiaging cosmetic treatments.
Author(s)
Gonzales-Masis, Jeimmy
Centro de Investigación y Extensión en Materiales, Escuela de Ciencia e Ingeniería de Los Materiales, Instituto Tecnológico de Costa Rica
Cubero-Sesin, Jorge M.
Centro de Investigación y Extensión en Materiales, Escuela de Ciencia e Ingeniería de Los Materiales, Instituto Tecnológico de Costa Rica
Corrales Ureña, Yendry Regina
National Laboratory of Nanotechnology LANOTEC, National Center of High Technology (CeNAT-CONARE), Pavas 1174-1200, San José, Costa Rica
González-Camacho, Sara
Biological Assay Laboratory (LEBi), Universidad de Costa Rica, San José 11501-2060, Costa Rica
Mora-Ugalde, Nohelia
National Center for Biotechnological Innovations (CENIBiot), National Center of High Technology (-CeNAT-CONARE), Pavas 1174-1200, San José, Costa Rica
Vega-Baudrit, José Roberto
National Laboratory of Nanotechnology LANOTEC, National Center of High Technology (CeNAT-CONARE), Pavas 1174-1200, San José, Costa Rica, Laboratorio de Polímeros (POLIUNA), Universidad Nacional, Heredia 86-3000, Costa Rica
Rischka, Klaus  
Fraunhofer-Institut für Fertigungstechnik und Angewandte Materialforschung IFAM  
Verma, Virendra
Ayurvedic Physician Private Clinic & Panchakarma Centre, Varanasi, India
Gonzalez-Paz, Rodolfo J.
National Laboratory of Nanotechnology LANOTEC, National Center of High Technology (CeNAT-CONARE), Pavas 1174-1200, San José, Costa Rica
Journal
International journal of biomaterials. Online journal  
Open Access
File(s)
Download (2.83 MB)
Rights
CC BY 4.0: Creative Commons Attribution
DOI
10.24406/publica-r-264443
10.1155/2020/3637098
Language
English
Fraunhofer-Institut für Fertigungstechnik und Angewandte Materialforschung IFAM  
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