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(Hybrid) SPECT and PET Technologies

: Nolte, T.; Gross-Weege, N.; Schulz, V.


Schober, O.:
Molecular Imaging in Oncology. Second Edition
Cham: Springer International Publishing, 2020 (Recent Results in Cancer Research 216)
ISBN: 978-3-030-42617-0 (Print)
ISBN: 978-3-030-42618-7 (Online)
ISBN: 978-3-030-42619-4
ISBN: 978-3-030-42620-0
Book Article
Fraunhofer MEVIS ()

SPECT and PET are nuclear tomographic imaging modalities that visualize functional information based on the accumulation of radioactive tracer molecules. However, SPECT and PET lack anatomical information, which has motivated their combination with an anatomical imaging modality such as CT or MRI. This chapter begins with an overview over the fundamental physics of SPECT and PET followed by a presentation of the respective detector technologies, including detection requirements, principles and different detector concepts. The reader is subsequently provided with an introduction into hybrid imaging concepts, before a dedicated section presents the challenges that arise when hybridizing SPECT or PET with MRI, namely, mutual distortions of the different electromagnetic fields in MRI on the nuclear imaging system and vice versa. The chapter closes with an overview about current hybrid imaging systems of both clinical and preclinical kind. Finally, future developments in hybrid SPECT and PET technology are discussed.