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Microglia differentiation and cell therapie

 
: Hinze, Arnd
: Grune, Tilman; Jungnickel, Berit; Bechmann, Ingo

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Fulltext ()

Jena, 2013, III, 116 pp.
Jena, Univ., Diss., 2013
URN: urn:nbn:de:gbv:27-20140513-133333-3
English
Dissertation, Electronic Publication
Fraunhofer IZI ()
Hirnkrankheit; Neuropsychiatrie; bone marrow stem cells; Mikroglia; GM-CSF; Neurodegeneration; Differenzierung

Abstract
Microglia Therapy: Diseases like Alzheimer or Multiple Sclerosis have been linked to a continuous deterioration of the resident microglia cell population. The brain, like other organs, also suffers from age related inflammation (“inflamm-aging”) and chronic activation of microglia. A cell therapy could aim to replace deteriorated microglia or to regulate the excessive activation of microglia in age. We wanted to differentiate microglia from adult stem cells (Paper 1 and 2) and to proof their function (phagocytosis, oxidative burst, migration). Then, we planned to transplant their progenitors and the differentiated microglia (Paper 3 and additional data). We also wanted to transplant mesenchymal stem cells (MSC) since MSC are known to regulate inflammation.

: http://publica.fraunhofer.de/documents/N-599750.html