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Actin networks voltage circuits

: Siccardi, Stefano; Adamatzky, Andrew; Tuszynski, Jack; Huber, Florian; Schnauß, Jörg


Physical Review. E 101 (2020), No.5, Art. 052314
ISSN: 1063-651X
ISSN: 1539-3755
ISSN: 2470-0045
ISSN: 2470-0053
ISSN: 1550-2376
Journal Article
Fraunhofer IZI ()
condensed matter; biological networks; applications of soft matter; electrical properties; organic electronics; biological physics; polymere; soft matter

Filaments of the cellular protein actin can form bundles, which can conduct ionic currents as well as mechanical and voltage solitons. These inherent properties can be utilized to generate computing circuits solely based on self-assembled actin bundle structures. Starting with experimentally observed networks of actin bundles, we model their network structure in terms of edges and nodes. We compute and discuss the main electrical parameters, considering the bundles as electrical wires with either low or high filament densities. A set of equations describing the network is solved with several initial conditions. Input voltages, which can be considered as information bits, are applied in a set of points and output voltages are computed in another set of positions. We consider both an idealized situation, where pointlike electrodes can be inserted in any points of the bundles and a more realistic case, where electrodes lay on a surface and have typical dimensions available in the industry. We find that in both cases such a system can implement the main logical gates and a finite state machine.