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Intravital cytometry and CYTO 2020. Editorial

: Tárnok, Attila


Cytometry. Part A 97 (2020), No.5, pp.444
ISSN: 1552-4922
ISSN: 0196-4763
ISSN: 1552-4930
Journal Article
Fraunhofer IZI ()

I welcome you to the May issue of Cytometry Part A. This issue is dedicated to intravital multiphoton microscopy. This beautiful technology enables observing and quantifying cell movement and interactions directly in the living object. This advanced and hot topic was chosen for the CYTO 2020 Philadelphia conference issue. However, now, the environment has substantially changed in many ways, leading unfortunately to the cancellation of CYTO 2020. But even with a tear in your eyes, you certainly will enjoy this focus issue. It is very relevant, with regard to viral infections, and is of high quality. I wish to express my gratitude to Raluca Niesner, Anja Hausner and David Entenberg for their enormous work and delivering of this important special issue. Read also their summary of the issue in their accompanying editorial (XXX).
So far, in vivo analysis of cells in live animals published in Cytometry Part A was mostly performed by in vivo flow cytometry 1-4 with the goal of detecting and eradicating circulating tumor cells. This technology produces flow cytometry‐like data per cell and not images. Original articles using intravital microscopy are rare so far 5. This special issue, therefore, also aims to motivate authors working with intravital multiphoton microscopy to submit their manuscripts in future.
Presently, very many of us are working from home, and most work or social interactions are restricted to the flat screen of computers and smart devices. In order to try to get back a bit to normality, each of us has his/her own strategies. Mine is, for example, to take a book or read some general scientific journals that have been lying on the shelf for ages waiting to be read. Last week, I came across an article that I found highly relevant to our present pandemic 6. It was about dengue fever and the mechanism of antibody‐dependent enhancement of a secondary infection by dengue. In light of SARS‐CoV‐2 and COVID‐19, this is a hot topic, and I will elaborate on it together with our Associate Editor Henning Ulrich from Sao Paulo in a separate short article.