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Dual modality multiphoton-OCT flexible endomicroscope with an integrated electromagnetic z-actuator for optical field-of-view switching and a piezo-fiber-scanner for image acquisition

: Meerschmidt, B.; Matz, G.; Flämig, S.; Reichwald, K.; Pshenay-Severin, E.; Kamm, A.; Reinlein, C.; Kopf, T.; Korn, B.; Kühnert, K.; Vasquez, D.; Heilmann, M.; Frank, T.; Sattel, T.; Ströhla, T.; Lu, X.; Gross, H.


Tearney, G.J. ; Society of Photo-Optical Instrumentation Engineers -SPIE-, Bellingham/Wash.:
Endoscopic Microscopy XV : 1–2 February 2020 San Francisco, California, United States
Bellingham, WA: SPIE, 2020 (Proceedings of SPIE 11214)
ISBN: 978-1-5106-3191-5
ISBN: 978-1-5106-3192-2
Art. 112140X, 14 pp.
Conference "Endoscopic Microscopy" <15, 2020, San Francisco/Calif.>
Conference Paper
Fraunhofer IOF ()

A miniature endomicroscope is presented that combines a large field-of-view (up to 1.7 mm) for OCT-imaging and a high-resolution mode with 360 μm field-of-view (NA = 0.5) for multi-photon fluorescence or OCT imaging. The 4.7x magnification variation is achieved by the axial positioning of an inner micro-optical lens group using an integrated electro-magnetic z-actuator. A reverse fiber-optic piezotube-scanner with minimized length is employed for the image acquisition by resonant spiral scanning. With the probe diameter of 2.7 mm and a rigid length of about 60 mm, the approach may pave the way to clinical applications of these two modalities in a single probe. © COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.