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Accuracy of a magnetic resonance imaging-based 3D printed stereotactic brain biopsy device in dogs

: Gutmann, Sarah; Winkler, Dirk; Müller, Marcel; Möbius, Robert; Fischer, Jean-Pierre; Böttcher, P.; Kiefer, Ingmar; Grunert, Ronny; Flegel, Thomas

Fulltext ()

Journal of veterinary internal medicine : JVIM 34 (2020), No.2, pp.844-851
ISSN: 0891-6640
ISSN: 1939-1676
Journal Article, Electronic Publication
Fraunhofer IWU ()
3D printing; MRI; brain biopsy; canine; neurosurgery; personalized

BACKGROUND: Brain biopsy of intracranial lesions is often necessary to determine specific therapy. The cost of the currently used stereotactic rigid frame and optical tracking systems for brain biopsy in dogs is often prohibitive or accuracy is not sufficient for all types of lesion.
OBJECTIVES: To evaluate the application accuracy of an inexpensive magnetic resonance imaging-based personalized, 3D printed brain biopsy device.
ANIMALS: Twenty-two dog heads from cadavers were separated into 2 groups according to body weight (<15 kg, >20 kg).METHODS: Experimental study. Two target points in each cadaver head were used (target point 1: caudate nucleus, target point 2: piriform lobe). Comparison between groups was performed using the independent Student's t test or the nonparametric Mann-Whitney U Test.
RESULTS: The total median target point deviation was 0.83 mm (range 0.09-2.76 mm). The separate median target point deviations for target points 1 and 2 in all dogs were 0.57 mm (range: 0.09-1.25 mm) and 0.85 mm (range: 0.14-2.76 mm), respectively.
CONCLUSION AND CLINICAL IMPORTANCE: This magnetic resonance imaging-based 3D printed stereotactic brain biopsy device achieved an application accuracy that was better than the accuracy of most brain biopsy systems that are currently used in veterinary medicine. The device can be applied to every size and shape of skull and allows precise positioning of brain biopsy needles in dogs.