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Ways forward for tolerance-inducing cellular therapies - an AFACTT perspective

: Brinke, A. ten; Martinze-Llordella, M.; Cools, N.; Hilkens, C.M.U.; Ham, S.M. van; Sawitzki, B.; Geissler, E.K.; Lombardi, G.; Trzonkowski, P.; Martinez-Caceres, E.

Fulltext urn:nbn:de:0011-n-5828113 (327 KByte PDF)
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Created on: 26.3.2020

Frontiers in Immunology 10 (2019), Art. 181, 20 pp.
ISSN: 1664-3224 (online)
Journal Article, Electronic Publication
Fraunhofer ITEM ()

Clinical studies with cellular therapies using tolerance-inducing cells, such as tolerogenic antigen-presenting cells (tolAPC) and regulatory T cells (Treg) for the prevention of transplant rejection and the treatment of autoimmune diseases have been expanding the last decade. In this perspective, we will summarize the current perspectives of the clinical application of both tolAPC and Treg, and will address future directions and the importance of immunomonitoring in clinical studies that will result in progress in the field.