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Optimizing product quality in molecular farming

: Schiermeyer, Andreas


Current opinion in biotechnology 61 (2020), pp.15-20
ISSN: 0958-1669
ISSN: 1879-0429
European Commission EC
H2020; 774078; Pharma-Factory
Building the product pipeline for commercial demonstration of Plant Molecular Factories
European Commission EC
H2020; 760331; Newcotiana
Developing Multipurpose Nicotiana Crops for Molecular Farming using New Plant Breeding Techniques
Journal Article
Fraunhofer IME ()

The production of biopharmaceuticals in plant-based systems had faced several challenges that hampered broader adoption of this technology. In recent years, various plant production hosts have been improved by genetic engineering approaches to overcome obstacles with regard to post-translational modifications and integrity of target proteins. Together with optimized extraction and purification processes, those advances have put plant molecular farming in a more competitive position compared to established production systems. Certain biopharmaceuticals can be derived from plant systems with unique desired properties, qualifying them as biobetters.