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Investigations on the Toxicity of CeO2 Nanoparticles after Subchronic Inhalation of Low Doses

: Schwotzer, Daniela
: Kietzmann, Manfred; Steinberg, Pablo; Dasenbrock, Clemens; Gebel, Thomas

Hannover, 2018, IV, 114 pp.
Hannover, Tierärztliche Hochschule, Diss., 2018
Fraunhofer ITEM ()
nanoparticles; barium sulfate; dose-response relationship; animal model; rat

The present research focused on the toxicology of nanomaterial. It was based on a 90day inhalation toxicity study with cerium oxide and barium sulfate nanoparticles, performed according to OECD TG 413. CeO2 is for example used as diesel fuel additive. BaSO4 is used in paintings and coatings. The project was an addition to a combined chronic inhalation toxicity and carcinogenicity study with CeO2 and BaSO4 (BASF, Ludwigshafen, Germany; NANoREG program, 81