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  4. Impact of organ-on-a-chip technology on pharmaceutical R&D costs
 
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2019
Journal Article
Title

Impact of organ-on-a-chip technology on pharmaceutical R&D costs

Abstract
Healthcare systems are faced with the challenge of providing innovative treatments, while shouldering high drug costs that pharmaceutical companies justify by the high costs of R&D. An emergent technology that could transform R&D efficiency is organ-on-a-chip. The technology bridges the gap between preclinical testing and human trials through better predictive models, significantly impacting R&D costs. Here, we present an expert survey on the future role of organ-on-a-chip in drug discovery and its potential quantitative impact. We find that the technology has the potential to reduce R&D costs significantly, driven by changes in direct costs, success rates and the length of the R&D process. Finally, we discuss regulatory challenges to efficiency improvements.
Author(s)
Franzen, Nora
Harten, Wim H. van
Retèl, Valesca P.
Loskill, Peter  
Eijnden-van Raaij, A.J.M. van den
Ijzerman, Maarten J.
Journal
Drug Discovery Today  
Open Access
DOI
10.1016/j.drudis.2019.06.003
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Language
English
Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik IGB  
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