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Impact of organ-on-a-chip technology on pharmaceutical R&D costs

 
: Franzen, Nora; Harten, Wim H. van; Retèl, Valesca P.; Loskill, Peter; Eijnden-van Raaij, A.J.M. van den; Ijzerman, Maarten J.

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Drug Discovery Today (2019), Online First, 5 pp.
ISSN: 1359-6446
ISSN: 1878-5832
English
Journal Article, Electronic Publication
Fraunhofer IGB ()

Abstract
Healthcare systems are faced with the challenge of providing innovative treatments, while shouldering high drug costs that pharmaceutical companies justify by the high costs of R&D. An emergent technology that could transform R&D efficiency is organ-on-a-chip. The technology bridges the gap between preclinical testing and human trials through better predictive models, significantly impacting R&D costs. Here, we present an expert survey on the future role of organ-on-a-chip in drug discovery and its potential quantitative impact. We find that the technology has the potential to reduce R&D costs significantly, driven by changes in direct costs, success rates and the length of the R&D process. Finally, we discuss regulatory challenges to efficiency improvements.

: http://publica.fraunhofer.de/documents/N-549697.html