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Therapy resistance beyond cellular dormancy

: Werner-Klein, M.; Klein, C.A.


Nature cell biology 21 (2019), No.2, pp.117-119
ISSN: 1465-7392
ISSN: 1476-4679
Journal Article
Fraunhofer ITEM ()

It is commonly accepted that disseminated tumour cells survive cytotoxic chemotherapy because they are not proliferating. A new study now finds that, in contrast to this long-standing concept, both dormant and proliferative cancer cells can be protected from chemotherapy when they reside at the perivascular niche.