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KDEL receptor regulates secretion by lysosome relocation- and autophagy-dependent modulation of lipid-droplet turnover

 
: Tapia, D.; Jimenez, T.; Zamora, C.; Espinoza, J.; Rizzo, R.; Gonzalez-Cardenas, A.; Fuentes, D.; Hernandez, S.; Cavieres, V.A.; Soza, A.; Guzman, F.; Arriagada, G.; Yuseff, M.I.; Mardones, G.A.; Burgos, P.V.; Luini, A.; Gonzalez, A.; Cancino, J.

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Fulltext ()

Nature Communications 10 (2019), Art. 735, 17 pp.
ISSN: 2041-1723
English
Journal Article, Electronic Publication
Fraunhofer Chile Research - Centro para la Biotecnología de Sistemas ()

Abstract
Inter-organelle signalling has essential roles in cell physiology encompassing cell metabolism, aging and temporal adaptation to external and internal perturbations. How such signalling coordinates different organelle functions within adaptive responses remains unknown. Membrane traffic is a fundamental process in which membrane fluxes need to be sensed for the adjustment of cellular requirements and homeostasis. Studying endoplasmic reticulum-to-Golgi trafficking, we found that Golgi-based, KDEL receptor-dependent signalling promotes lysosome repositioning to the perinuclear area, involving a complex process intertwined to autophagy, lipid-droplet turnover and Golgi-mediated secretion that engages the microtubule motor protein dynein-LRB1 and the autophagy cargo receptor p62/SQSTM1. This process, here named ‘traffic-induced degradation response for secretion’ (TIDeRS) discloses a cellular mechanism by which nutrient and membrane sensing machineries cooperate to sustain Golgi-dependent protein secretion.

: http://publica.fraunhofer.de/documents/N-549397.html