Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.

Heterotypic Ubiquitin Chains: Seeing is Believing

: Stolz, A.; Dikic, I.


Trends in cell biology 28 (2018), No.1, pp.1-3
ISSN: 0962-8924
ISSN: 1879-3088
Journal Article
Fraunhofer IME ()

The biological diversity of ubiquitination resides in the multivalent nature of linkage-specific homotypic and heterotypic ubiquitin (Ub) chains. A recent publication by Yau et al. in Cell describes the development of K11/K48-bispecific antibodies and a physiological role for K11/K48 heterotypic chains in regulation of the cell cycle and clearance of aggregated proteins.