Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.

Surface evaluation of titanium oxynitride coatings used for developing layered cardiovascular stents

 
: Beshchasna, Nataliia; Kwan Ho, Au Yeung; Saqib, Muhammad; Kraśkiewicz, Honorata; Wasyluk, Łukasz; Kuzmin, Oleg; Duta, Oana; Ficai, Denisa; Trusca, Roxana; Ficai, Anton; Pichugin, Vladimir F.; Opitz, Jörg; Andronescu, Ecaterina

:

Materials Science and Engineering, C. Biomimetic and supramolecular systems Biomimetic materials, sensors and systems 99 (2019), pp.405-416
ISSN: 0928-4931
ISSN: 1873-0191
Bundesministerium für Bildung und Forschung BMBF (Deutschland)
01DJ15023; TiOxTech-Bio
Titanoxidnitrid-Beschichtungen für die Verbesserung der Biokompatibilität und Langzeitfunktionalität von kardiovaskulären Stents: Entwicklung der neuen Beschichtungstechnologie
English
Journal Article
Fraunhofer IKTS ()
magnetron sputtering; titanium oxynitride coating; cardiovascular stent; surface evaluation by SEM; EDX and FTIR; protein adsorption; biological assessment; static and dynamic exposure to simulated body fluids; in-vitro biocompatibility; electrochemical

Abstract
Stents are important medical devices used to increase the quality and life expectancy of patients with heart diseases and stroke, leading causes of death, worldwide. In order to minimize the risk of restenosis, different coating on bare metal stents (BMS) such as polymer coatings; titanium dioxide, titanium nitride or titanium oxynitride coatings; carbon coatings and others are used. The aim of this work was to develop novel stents coated with titanium oxynitride (TiOxNy) with optimal chemical, mechanical and biological properties having possibly good coverage rate of inner and outer stent surfaces. The improvement should be achieved by optimization and development of a magnetron sputtering deposition technology. The goal of the study is understanding of the existing potential for improvement of the deposition technology and the coating quality itself. For this study, different O2/N2 ratios, meaning 1/2, 1/5 and 1/10 (the ratios of reagent gasses are given for the values of mass flows into the chamber) has been selected. Stability in simulated body fluids, surface morphology and protein adsorption as well as preliminary cytotoxic behaviour of the samples on HUVEC cells has been analysed. SEM experiments have shown the potential in the improvement of coating-stent adhesion by all samples. TiOxNy 1:5 samples were found to have the lowest adsorption, the smoothest surface morphology and the smallest rate of salt deposition from simulated body fluids (SBFs). This kind of surface has been recommended for further optimization and application.

: http://publica.fraunhofer.de/documents/N-534459.html