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  4. Stabilization and sterilization of pericardial scaffolds by ultraviolet and low-energy electron irradiation
 
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2018
Journal Article
Title

Stabilization and sterilization of pericardial scaffolds by ultraviolet and low-energy electron irradiation

Abstract
Pericardium-based tissue transplantation is a lifesaving treatment. Commercial glutaraldehyde-treated pericardial tissue exhibits cytotoxicity, which is associated with the accelerated graft failure. Replacement of glutaraldehyde has been suggested to overcome those drawbacks. In this study, we report a toxin-free method that combines tissue stabilization with a terminal sterilization. Our data indicate that the SULEEI procedure, which is part of an issued patent, may be a promising first step toward glutaraldehyde-free pericardium-based tissue transplants. Thus, our results may contribute to improving cardiovascular treatment strategies.
Author(s)
Walker, Simona
Fraunhofer-Institut für Organische Elektronik, Elektronenstrahl- und Plasmatechnik FEP  
Schönfelder, Jessy  
Fraunhofer-Institut für Organische Elektronik, Elektronenstrahl- und Plasmatechnik FEP  
Tugtekin, Sems-Malte
Department of Cardiac Surgery, Faculty of Medicine CGC, Technische Universität Dresden, Herzzentrum Dresden, Dresden, Germany
Wetzel, Christiane
Fraunhofer-Institut für Organische Elektronik, Elektronenstrahl- und Plasmatechnik FEP  
Hacker, Michael C.
Institute of Pharmacy, Pharmaceutical Technology, Faculty of Medicine, Leipzig University, Leipzig, Germany
Schulz-Siegmund, Michaela
Institute of Pharmacy, Pharmaceutical Technology, Faculty of Medicine, Leipzig University, Leipzig, Germany
Journal
Tissue engineering. Part C, Methods  
Open Access
DOI
10.1089/ten.tec.2018.0285
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Language
English
Fraunhofer-Institut für Organische Elektronik, Elektronenstrahl- und Plasmatechnik FEP  
Keyword(s)
  • sterilization

  • pericardium

  • low-energy electron irradiation

  • ionizing irradiation

  • low energy

  • glutaraldehyde

  • SULEEI

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