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2018
Journal Article
Titel
Stabilization and sterilization of pericardial scaffolds by ultraviolet and low-energy electron irradiation
Abstract
Pericardium-based tissue transplantation is a lifesaving treatment. Commercial glutaraldehyde-treated pericardial tissue exhibits cytotoxicity, which is associated with the accelerated graft failure. Replacement of glutaraldehyde has been suggested to overcome those drawbacks. In this study, we report a toxin-free method that combines tissue stabilization with a terminal sterilization. Our data indicate that the SULEEI procedure, which is part of an issued patent, may be a promising first step toward glutaraldehyde-free pericardium-based tissue transplants. Thus, our results may contribute to improving cardiovascular treatment strategies.
Author(s)
Walker, Simona
Tugtekin, Sems-Malte
Department of Cardiac Surgery, Faculty of Medicine CGC, Technische Universität Dresden, Herzzentrum Dresden, Dresden, Germany
Wetzel, Christiane
Hacker, Michael C.
Institute of Pharmacy, Pharmaceutical Technology, Faculty of Medicine, Leipzig University, Leipzig, Germany