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Preparation and characterization of Chilean propolis coprecipitates using Supercritical Assisted Atomization

: Capua, A. di; Bejarano, A.; Adami, R.; Reverchon, E.


Transactions of the Institution of Chemical Engineers. A 136 (2018), pp.776-785
ISSN: 0263-8762
Journal Article
Fraunhofer Chile Research - Centro para la Biotecnología de Sistemas ()

Propolis is a natural resinous material with antimicrobial, anti-inflammatory, antioxidant, antibiotic and anti-carcinogenic properties. Propolis coprecipitation was attempted by Supercritical Assisted Atomization (SAA) using two carriers: hydroxypropyl-β-cyclodextrin (HPβCD) and polyvinylpyrrolidone (PVP), with the aim to protect propolis bioactivity against oxidation and to improve its bioavailability. Propolis/carrier ratio and overall solute concentration were investigated to understand their effect on the success of coprecipitation as solid dispersion of propolis in the carrier matrix and on particle morphology and particle size distribution. The results confirmed the efficiency of SAA process: spherical amorphous particles were obtained in which propolis and carrier were coprecipitated, with a mean diameter ranging between about 0.20 and 0.37 μm for HPβCD coprecipitates and between about 0.23 and 0.50 μm for PVP coprecipitates. SAA particles showed a polyphenol loading efficiency up to 100% for HPβCD coprecipitates and up to 96% for PVP coprecipitates, with a half inhibition concentration of DPPH radical up to (17.2 ± 2.8) μg/mL and (17.3 ± 1.0) μg/mL, respectively. These particles rich in bioactive compounds can be used as functional component in formulations of new food or pharmaceutical products.