Publica
Hier finden Sie wissenschaftliche Publikationen aus den FraunhoferInstituten. IMRT planning on adaptive volume structures  A decisive reduction in computational complexity
 Physics in medicine and biology 50 (2005), No.9, pp.20332053 ISSN: 00319155 

 English 
 Journal Article 
 Fraunhofer ITWM () 
Abstract
The objective of radiotherapy planning is to find a compromise between the contradictive goals of delivering a sufficiently high dose to the target volume while widely sparing critical structures. The search for such a compromise requires the computation of several plans, which mathematically means solving several optimization problems. In the case of intensity modulated radiotherapy (IMRT) these problems are largescale, hence the accumulated computational expense is very high. The adaptive clustering method presented in this paper overcomes this difficulty. The main idea is to use a preprocessed hierarchy of aggregated dosevolume information as a basis for individually adapted approximations of the original optimization problems. This leads to a decisively reduced computational expense: numerical experiments on several sets of real clinical data typically show computation times decreased by a factor of about 10. In contrast to earlier work in this field, this reduction in computational complexity will not lead to a loss in accuracy: the adaptive clustering method produces the optimum of the original optimization problem.