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Comparison of quantitative regional ventilation‐weighted fourier decomposition MRI with dynamic fluorinated gas washout MRI and lung function testing in COPD patients

: Kaireit, Till F.; Gutberlet, Marcel; Voskrebenzev, Andreas; Freise, Julia; Welte, Tobias; Hohlfeld, Jens M.; Wacker, Frank; Vogel-Claussen, Jens


Journal of magnetic resonance imaging 47 (2018), 6, pp.1534-1541
ISSN: 1053-1807
Journal Article
Fraunhofer ITEM ()
19F; COPD; fourier decomposition; free breathing; lung function test; washout

BACKGROUND: Ventilation-weighted Fourier decomposition-MRI (FD-MRI) has matured as a reliable technique for quantitative measures of regional lung ventilation in recent years, but has yet not been validated in COPD patients.
PURPOSE/HYPOTHESIS: To compare regional fractional lung ventilation obtained by ventilation-weighted FD-MRI with dynamic fluorinated gas washout MRI ((19) F-MRI) and lung function test parameters.
STUDY TYPE: Prospective study.
POPULATION: Twenty-seven patients with chronic obstructive pulmonary disease (COPD, median age 61 [54-67] years) were included.
FIELD STRENGTH/SEQUENCE: For FD-MRI and for (19) F-MRI a spoiled gradient echo sequence was used at 1.5T.
ASSESSMENT: FD-MRI coronal slices were acquired in free breathing. Dynamic (19) F-MRI was performed after inhalation of 25-30 L of a mixture of 79% fluorinated gas (C3 F8 ) and 21% oxygen via a closed face mask tubing using a dedicated coil tuned to 59.9 MHz. (19) F washout times in numbers of breaths ((19) F-nbreaths ) as well as fractional ventilation maps for both methods (FD-FV, (19) F-FV) were calculated. Slices were matched using a landmark driven algorithm, and only corresponding slices with an overlap of >90% were coregistered for evaluation.
STATISTICAL TESTS: The obtained parameters were correlated with each other using Spearman's correlation coefficient (r).
RESULTS: FD-FV strongly correlated with (19) F-nbreaths on a global (r = -0.72, P < 0.0001) as well as on a lobar level and with lung function test parameters (FD-FV vs. FEV1, r = 0.76, P < 0.0001). There was a small systematic overestimation of FD-FV compared to (19) F-FV (mean difference -0.03 (95% confidence interval [CI]: -0.097; -0.045).
DATA CONCLUSION: Regional ventilation-weighted Fourier decomposition-MRI is a promising noninvasive, radiation-free tool for quantification of regional ventilation in COPD patients.