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The Sierra Platinum Service for generating peak-calls for replicated ChIP-seq experiments

: Wiegreffe, Daniel; Müller, Lydia; Steuck, Jens; Zeckzer, Dirk; Stadler, Peter F.

Fulltext ()

BMC research notes. Online journal 11 (2018), Art. 512, 5 pp.
ISSN: 1756-0500
Journal Article, Electronic Publication
Fraunhofer IZI ()
ChIP-seq; histone modification; peak-caller; replicate analysis

Objective: Sierra Platinum is a fast and robust peak-caller for replicated ChIP-seq experiments with visual quality-control and -steering. The required computing resources are optimized but still may exceed the resources available to researchers at biological research institutes.
Results: Sierra Platinum Service provides the full functionality of Sierra Platinum: using a web interface, a new instance of the service can be generated. Then experimental data is uploaded and the computation of the peaks is started. Upon completion, the results can be inspected interactively and then downloaded for further analysis, at which point the service terminates.