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Engineering von intrazellulären Modulatoren

Engineering of intracellular modulators
: Wiechmann, S.; Ernst, A.


Biospektrum 23 (2017), No.7, pp.769-771
ISSN: 0947-0867
ISSN: 1868-6249
Journal Article
Fraunhofer IME ()

The engineering of affinity reagents has become a standard technology in modern drug development efforts. High-throughput screening of recombinant protein libraries has yielded numerous affinity reagents that are used in diagnostic or therapeutic applications. In our approach, we engineer intracellular affinity reagents by enhancing pre-existing intermolecular contacts to target functional epitopes in proteins. The designed affinity reagents allow a fast and specific interrogation of druggable sites in therapeutic relevant proteins.