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Evaluation of the dose-response and fate in the lung and pleura of chrysotile-containing brake dust compared to chrysotile or crocidolite asbestos in a 28-day quantitative inhalation toxicology study

: Bernstein, D.M.; Tóth, B.; Rogers, R.A.; Sepulveda, R.; Kunzendorf, P.; Phillips, J.I.; Ernst, Heinrich

Fulltext urn:nbn:de:0011-n-4977233 (6.8 MByte PDF)
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Created on: 10.7.2018

Toxicology and Applied Pharmacology 351 (2018), pp.74-92
ISSN: 0041-008X
Journal Article, Electronic Publication
Fraunhofer ITEM ()

This study provides an understanding of the biokinetics and potential toxicology in the lung and pleura following inhalation of brake-dust (brakes manufactured with chrysotile). The design included a 28-day repeated multi-dose inhalation exposure (6h/d, 5 d/wk, 4 wks) followed by 28-days without exposure. Fiber control groups included a similar grade chrysotile as used in the brakes and a commercial crocidolite asbestos. Aerosol fiber distributions of the chrysotile and crocidolite were similar (fiber-length>20mum/cm(3): Chrysotile-low/high 42/62; Crocidolite-low/high 36/55; WHO-fibers/cm(3): Chrysotile-low/high 192/219; Crocidolite-low/high 211/255). The total number of aerosol particles/cm(3) in the brake-dust was similar to that in the chrysotile (Brake-dust 710-1065; Chrysotile 532-1442). Brake-dust at particle exposure levels equal to or greater than chrysotile or crocidolite caused no indication of microgranulomas, epithelial hyperplasia, or fibrosis (Wagner score<1.7) or changes in bronchoalveolar lavage (BAL) indices from the air control. Chrysotile BAL indices did not differ from the air control. Pathologically, there was low level of inflammation and epithelial hyperplasia, but no fibrosis (Wagner score