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New stereolithographic resin providing functional surfaces for biocompatible three-dimensional printing

: Hoffmann, A.; Leonards, H.; Tobies, N.; Pongratz, L.; Kreuels, K.; Kreimendahl, F.; Apel, C.; Wehner, M.; Nottrodt, N.

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Journal of tissue engineering : JTE 8 (2017), pp.1-9
ISSN: 2041-7314
Journal Article, Electronic Publication
Fraunhofer ILT ()

Stereolithography is one of the most promising technologies for the production of tailored implants. Within this study, we show the results of a new resin formulation for three-dimensional printing which is also useful for subsequent surface functionalization. The class of materials is based on monomers containing either thiol or alkene groups. By irradiation of the monomers at a wavelength of 266 nm, we demonstrated an initiator-free stereolithographic process based on thiol-ene click chemistry. Specimens made from this material have successfully been tested for biocompatibility. Using Fourier-transform infrared spectrometry and fluorescent staining, we are able to show that off-stoichiometric amounts of functional groups in the monomers allow us to produce scaffolds with functional surfaces. We established a new protocol to demonstrate the opportunity to functionalize the surface by copper-catalyzed azide-alkyne cycloaddition chemistry. Finally, we demonstrate a three-dimensional bioprinting concept for the production of potentially biocompatible polymers with thiol-functionalized surfaces usable for subsequent functionalization.