Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.

Gene phylogenies and orthologous groups

: Setubal, João C.; Stadler, Peter F.


Setubal, J.C.:
Comparative genomics. Methods and protocols
New York/NY: Springer Science+Business Media, 2018 (Methods in molecular biology 1704)
ISBN: 978-1-4939-7461-0 (Print)
ISBN: 978-1-4939-7463-4 (Online)
Book Article
Fraunhofer IZI ()
gene family; ortholog; paralog; phylogeny; protein family

This chapter covers the theory and practice of ortholog gene set computation. In the theoretical part we give detailed and formal descriptions of the relevant concepts. We also cover the topic of graph-based clustering as a tool to compute ortholog gene sets. In the second part we provide an overview of practical considerations intended for researchers who need to determine orthologous genes from a collection of annotated genomes, briefly describing some of the most popular programs and resources currently available for this task.