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High-antifouling polymer brush coatings on nonpolar surfaces via adsorption-cross-linking strategy

: Lu, Leixiao; Hou, Yong; Cheng, Chong; Schlaich, Christoph; Noeske, Paul-Ludwig Michael; Wei, Qiang; Haag, Rainer


ACS applied materials & interfaces 9 (2017), No.51, pp.44281-44292
ISSN: 1944-8244
ISSN: 0013-936X
ISSN: 1944-8252
Journal Article
Fraunhofer IFAM ()
polymer brush coating; adsorption-cross-linking; low-energy surface modification; low fouling; biospecific surface

A new “adsorption-cross-linking” technology is presented to generate a highly dense polymer brush coating on various nonpolar substrates, including the most inert and low-energy surfaces of poly(dimethyl siloxane)and poly(tetrafluoroethylene). This prospective surface modification strategy is based on a tailored bifunctional amphiphilic block copolymer with benzophenone units as the hydrophobic anchor/chemical cross-linker and terminal azide groups for in situ postmodification. The resulting polymer brushes exhibited long-term and ultralow protein adsorption and cell adhesion benefiting from the high density and high hydration ability of polyglycerol blocks. The presented antifouling brushes provided a highly stable and robust bioinert background for biospecific adsorption of desired proteins and bacteria after secondary modification with bioactive ligands, e.g., mannose for selective ConA and Escherichia coli binding.