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Labbag® - a versatile bag-based cultivation system for expansion, differentiation and cryopreservation of human stem cells

: Gepp, Michael; Duckstein, Rowena; Kayatz, Fabian; Rodler, Norbert; Scheuerer, Zuzana; Neubauer, Julia; Lachmann, Kristina; Stramm, Cornelia; Liebmann, Andrea; Thomas, Michael; Zimmermann, Heiko

Fulltext urn:nbn:de:0011-n-4743699 (490 KByte PDF)
MD5 Fingerprint: 16c7a5852d3bfda40928e55dc1226542
(CC) by-nc-nd
Created on: 5.12.2017

Current directions in biomedical engineering 3 (2017), No.2, pp.371-374
ISSN: 2364-5504
Journal Article, Electronic Publication
Fraunhofer IBMT ()
Fraunhofer IST ()
Fraunhofer IVV ()

Novel approaches in regenerative medicine and tissue engineering are highly promoted by human induced pluripotent stem cells. Typical workflows include the expansion, differentiation and/or cryopreservation of these cells. Often, the differentiation, cytotoxicity tests or disease modelling rely on multicellular aggregates. Here, we present the novel bag-based system “Labbag®” to address workflows required for these applications. As a unique feature, the Labbag® provides a chemical spot pattern to allow the formation of several hundreds of hanging droplets within a few seconds with standard laboratory equipment. In this study, we describe the general concept of the Labbag® and show aggregate formation of stem cells as first stem cell workflow successfully transferred.