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Dual-stimuli sensitive hybrid materials: Ferritin-PDMAEMA by grafting-from polymerization

: Tebaldi, Marli Luiza; Charan, Himanshu; Mavliutova, Liliia; Böker, Alexander; Glebe, Ulrich


Macromolecular chemistry and physics 218 (2017), No.11, Art. 1600529, 6 pp.
ISSN: 1022-1352
Bundesministerium für Bildung und Forschung BMBF
031A164C; Chirale Membranen
Journal Article
Fraunhofer IAP ()

The combination of stimuli-responsive polymers and proteins that can transport drugs is a promising approach for drug delivery. The formation of ferritin–poly(2-dimethylaminoethyl methacrylate) (PDMAEMA) conjugates by atom-transfer radical polymerization from the protein macroinitiator is described. PDMAEMA is a dual-stimuli-responsive polymer and the thermo- and pH-responsive properties of the resulting conjugates are studied in detail with dynamic light scattering (DLS). Additionally, it is demonstrated that the lower critical solution temperature (LCST) of the protein–polymer conjugates can be further adjusted by the ionic strength of the solution. The conjugates are also characterized by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), matrix-assisted laser desorption ionization-time of flight (MALDI-ToF) mass spectrometry, and NMR spectroscopy. The obtained MALDI-ToF mass spectra are exceptional for protein–polymer conjugates and have not been so often reported.