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Automated tissue dissociation for rapid extraction of viable cells

: McBeth, Christine; Gutermuth, Angela; Ochs, Jelena; Sharon, Andre; Sauer-Budge, Alexis F.

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Procedia CIRP 65 (2017), pp.88-92
ISSN: 2212-8271
Conference on BioManufacturing (BioM) <3, 2017, Chicago/Ill.>
Journal Article, Conference Paper, Electronic Publication
Fraunhofer IPT ()
Fraunhofer CMI ()
Automatisierung; Medizintechnik

Viable cells from healthy tissues are a rich resource in high demand for many next-generation therapeutics and regenerative medicine applications. Cell extraction from the dense connective matrix of most tissues is a labor-intensive task and high variability makes cGMP compliance difficult. To reduce costs and ensure greater reproducibility, automated tissue dissociators compatible with robotic liquid handling systems are required. Here we demonstrate the utility of our automated tissue dissociator that is compatible with standard microtiter well plates for high-throughput processing. We show that viable cell yields match or exceed manual methods while reducing processing time by at least 85%.