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Herpesviral vectors and their application in oncolytic therapy, vaccination, and gene transfer

: Bailer, S.M.; Funk, C.; Riedl, A.; Ruzsics, Z.


Virus genes 53 (2017), No.5, pp.741-748
ISSN: 0920-8569 (Print)
ISSN: 1572-994X (Online)
Journal Article
Fraunhofer IGB ()

Herpesviruses are enveloped DNA viruses that infect vertebrate cells. Their high potential cloning capacity and the lifelong persistence of their genomes in various host cells make them attractive platforms for vector-based therapy. In this review, we would like to highlight recent advances of three major areas of herpesvirus vector development and application: (i) oncolytic therapy, (ii) recombinant vaccines, and (iii) large capacity gene transfer vehicles.