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MIP-esterase/Tyrosinase combinations for Paracetamol and Phenacetin

 
: Yarman, A.; Scheller, F.W.

:

Electroanalysis 28 (2016), No.9, pp.2222-2227
ISSN: 1040-0397
ISSN: 1521-4109
English
Journal Article
Fraunhofer IZI ()

Abstract
A new electrochemical MIP sensor for the most frequently used drug paracetamol (PAR) was prepared by electropolymerization of mixtures containing the template molecule and the functional monomers o-phenylenediamine, resorcinol and aniline. The imprinting factor of 12 reflects the effective target binding to the MIP as compared with the non-imprinted electropolymer. Combination of the MIP with a nonspecific esterase allows the measurement of phenacetin â another analgesic drug. In the second approach the PAR containing sample solution was pretreated with tyrosinase in order to prevent electrochemical interferences by ascorbic acid and uric acid. Interference-free indication at a very low electrode potential without fouling of the electrode surface was achieved with the o-phenylenediamine: resorcinol-based MIP.

: http://publica.fraunhofer.de/documents/N-445269.html