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Rapid on-chip detection of Chlamydia trachomatis for home-care using loop-mediated isothermal amplification

 
: Tröger, V.; Scherber, A.; Moos, D.; Howitz, S.; Bohatzsch, T.; Lehes, M.; Tulp, I.; Kuhlmeier, D.

Chemical and Biological Microsystems Society -CBMS-, San Diego/Calif.:
20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. Vol.2 : Dublin, Ireland, 9-13 October 2016
Red Hook, NY: Curran, 2016
ISBN: 978-1-5108-3416-3
ISBN: 9780979806490
pp.617-618
International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS) <20, 2016, Dublin>
English
Conference Paper
Fraunhofer IZI ()

Abstract
Chlamydiae are intracellular bacterial pathogens having the ability to cause persistent, often subclinical and mainly sexually transmitted infection (STI). Here, we present a microfluidic device for early diagnosis of STIs. The microfluidic set-up integrates an isothermal nucleic acid amplification driven by internal chemical heating and the detection of the specific amplification product on a lateral flow-based strip. This simple and disposable test platform for the screening of pathogenic Chlamydia trachomatis is a promising tool in home-care diagnosis.

: http://publica.fraunhofer.de/documents/N-445079.html