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Overloading of lung clearance during chronic exposure of experimental animals to particles

: Muhle, H.; Bellmann, B.; Heinrich, U.


The Annals of occupational hygiene 32 (1988), No.inhaled particles VI, pp.141-147
ISSN: 0003-4878
ISSN: 1475-3162
Journal Article
Fraunhofer ITEM ()

Rats and hamsters inhaled different mineral dusts (Ti02, fly ash from coal fired power plants, man made mineral fibres) or combustion products (cigarette smoke, diesel or gasoline motor exhaust, coal oven exhaust). The effect of exposure on the clearance kinetics of labelled particles of59Fe203 was investigated. This probe aerosol was inhaled for one hour at different times of the chronic exposure. Lung clearance was measured by the decrease of the y-activity in the thoracic area for up to 80 days after this procedure. Chronic exposure was continued during this time. Results show an increase of the half-time of the deep lung clearance in animals which were exposed to a particle concentration of 3-14 mg/m3 for several months. The gaseous components of the combustion products were of minor importance in respect to lung clearance. © 1988 The British Occupational Hygiene Society.