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Differential lower airway dendritic cell patterns may reveal distinct endotypes of RSV bronchiolitis

: Kerrin, A.; Fitch, P.; Errington, C.; Kerr, D.; Waxman, L.; Riding, K.; McCormack, J.; Mehendele, F.; McSorley, H.; MacKenzie, K.; Wronski, S.; Braun, A.; Levin, R.; Theilen, U.; Schwarze, J.


Thorax 72 (2017), No.7, pp.620-627
ISSN: 0040-6376
ISSN: 1468-3296
Journal Article
Fraunhofer ITEM ()

Rationale The pathogenesis of respiratory syncytial virus (RSV) bronchiolitis in infants remains poorly understood. Mouse models implicate pulmonary T cells in the development of RSV disease. T cell responses are initiated by dendritic cells (DCs), which accumulate in lungs of RSV-infected mice. In infants with RSV bronchiolitis, previous reports have shown that DCs are mobilised to the nasal mucosa, but data on lower airway DC responses are lacking. Objective To determine the presence and phenotype of DCs and associated immune cells in bronchoalveolar lavage (BAL) and peripheral blood samples from infants with RSV bronchiolitis. Methods Infants intubated and ventilated due to severe RSV bronchiolitis or for planned surgery (controls with healthy lungs) underwent non-bronchoscopic BAL. Immune cells in BAL and blood samples were characterised by flow cytometry and cytokines measured by Human V-Plex Pro-inflammatory Panel 1 MSD kit.