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Evaluation of acute-to-chronic ratios of fish and Daphnia to predict acceptable no-effect levels

 
: May, M.; Drost, W.; Germer, S.; Juffernholz, T.; Hahn, S.

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Environmental Sciences Europe : ESEU 28 (2016), No.1, 9 pp.
ISSN: 2190-4715
ISSN: 2190-4707
English
Journal Article, Electronic Publication
Fraunhofer ITEM ()

Abstract
Background: Acute-to-chronic extrapolation is an important approach to predict acceptable no-effect levels from acute data which has some uncertainties, but is valuable for risk assessment of chemical substances. With regard to the still limited and heterogenic data of chronic fish tests, conclusions on aquatic hazard estimation need to be checked and the question arises whether the chronic toxicity to fish can be adequately derived from acute data. A comprehensive dataset including ecotoxicological studies of 203 substances was used to investigate acute-to-chronic ratios (ACR) for both fish and Daphnia. To address potential uncertainty parameters of the approach, the influence of the octanolâwater partition coefficient Kow, the mode of action, and the acute toxicity levels on the ACR was evaluated. Results: For industrial chemicals, median ACRs of 12.0 for fish and 8.8 for Daphnia and 90th percentiles of 68.0 and 50.2, respectively, were determined.

: http://publica.fraunhofer.de/documents/N-422082.html