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Does concomitant methotrexate with adalimumab influence treatment outcomes in patients with psoriatic arthritis? Data from a large observational study

: Behrens, F.; Koehm, M.; Arndt, U.; Wittig, B.M.; Greger, G.; Thaci, D.; Scharbatke, E.; Tony, H.-P.; Burkhardt, H.

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The Journal of Rheumatology 43 (2016), No.3, pp.632-639
ISSN: 0315-162X
Journal Article, Electronic Publication
Fraunhofer IME ()

Objective. To examine the influence of concomitant methotrexate (MTX) with adalimumab (ADA) on outcomes in patients with psoriatic arthritis (PsA) using data from an observational study of ADA. Methods. Data from a German noninterventional study of patients with PsA starting treatment with ADA were analyzed retrospectively for effects of concomitant MTX on key outcomes, including Disease Activity Score-28 joints, tender and swollen joint counts, skin assessments, and safety. Patients were categorized into those with symptoms of axial involvement and those with no symptoms of axial involvement as judged by the examining clinician. Results. A total of 1455 patients met the study criteria, 296 with axial involvement (ADA monotherapy = 165 plus MTX = 131) and 1159 with no axial involvement (ADA monotherapy = 658 plus MTX = 501).