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Mechanical Properties of Aligned Nanotopologies for Directing Cellular Behavior

: Zhou, Q.; Wünnemann, P.; Kühn, P.T.; Vries, J. de; Helmin, M.; Böker, A.; Kooten, T.G. van; Rijn, P. van


Advanced materials interfaces 3 (2016), No.18, art. 1600275
ISSN: 2196-7350
Journal Article
Fraunhofer IAP ()


Tailoring cell–surface interactions is important for the of design medical implants as well as regenerative medicine and tissue engineering materials. Here the single parameter system is transcended via translating hard nanotopology into soft polymeric hydrogel structures via hydrogel imprinting lithography. The response of these cells to the nanotopology of the same dimensions but with different mechanical properties displays unexpected behavior between “hard” tissue cells and “soft” tissue cells.