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Biodegradation-resistant multilayers coated with gold nanoparticles

Toward a tailor-made artificial extracellular matrix
: Prokopovic, Vladimir Z.; Vikulina, Anna S.; Sustr, David; Duschl, Claus; Volodkin, Dmitry V.


ACS applied materials & interfaces 8 (2016), No.37, pp.24345-24349
ISSN: 1944-8244
ISSN: 0013-936X
ISSN: 1944-8252
Journal Article
Fraunhofer IZI ()
cell adhesion; diffusion; enzymatic degradation; fluorescence recovery after photobleaching; hyaluronic acid; layer-by-layer; polylysine; semipermeable

Polymer multicomponent coatings such as multilayers mimic an extracellular matrix (ECM) that attracts significant attention for the use of the multilayers as functional supports for advanced cell culture and tissue engineering. Herein, biodegradation and molecular transport in hyaluronan/polylysine multilayers coated with gold nanoparticles were described. Nanoparticle coating acts as a semipermeable barrier that governs molecular transport into/from the multilayers and makes them biodegradation-resistant. Model protein lysozyme (mimics of ECM-soluble signals) diffuses into the multilayers as fast- and slow-diffusing populations existing in an equilibrium. Such a composite system may have high potential to be exploited as degradation-resistant drug-delivery platforms suitable for cell-based applications.