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Cystochromones, Unusual Chromone-Containing Polyketides from the Myxobacterium Cystobacter sp. MCy9104

: Nadmid, S.; Plaza, A.; Garcia, R.; Müller, R.


Journal of natural products 78 (2015), No.8, pp.2023-2028
ISSN: 0163-3864 (Print)
ISSN: 1520-6025 (Online)
Journal Article
Fraunhofer IME ()

Seven new chromone-containing polyketides, termed cystochromones A-G, were isolated from the myxobacterial strain Cystobacter sp. MCy9104. Their structures were elucidated using comprehensive NMR spectroscopy and HR-MS/MS. Cystochromones bear a pentadecyl moiety unusually attached at C-5 of the chromone ring. Moreover, isotope-labeled substrate feeding experiments and NMR analysis suggested a hybrid iso-fatty acid and polyketide synthase biosynthetic pathway for these secondary metabolites.