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New Developments to Synthetic Tissue Adhesives

Presentation held at the 6th Freiberg Collagen Symposium, September 14 to 15, 2016
Neue Entwicklungen zu synthetischen Gewebeklebstoffen
: Bohrisch, Jörg; Stachel, Ines

2016, 25 Folien
Freiberger Kollagensymposium <6, 2016, Freiberg>
Fraunhofer IAP ()
Tissue adhesives; Functional polymers
Anfrage beim Institut / Available on request from the institute

There is still a great need for tissue adhesives, which adhere inside the body very fast and possess good mechanical strength and excellent biocompatibility. The requirements for materials to be used in tissue adhesion (e. g. bonding of collagen hernia meshes) are diverse and sometimes conflicting. The resulting bond has to be mechanically strong but simultaneously elastic; it has to be durable and biodegradable at once. The process of adhesion has to be fast without generating too much heat. That is why medical adhesives are intended to be reactive. At the same time, they need to be storable and sterilizable. Currently, commercially available tissue adhesives represent a compromise of all these different requirements and are used very specifically for each individual case. In the present study, we demonstrate the potential of different adhesive principles taken from the literature or from our own developments by bonding collagen-based surfaces in a standard test procedure. Commonly used tissue glues based on cyanoacrylate or fibrin serve as reference materials for comparison and collagen casing, pigskin as well as a commercially available collagen matrix (Xenoderm®) are used as tissue-like surfaces to be sticked together. Three groups of potential adhesives were analyzed: polymers that contain catechol-groups and are oxidatively activated (keyword: mussel glue), acrylic compounds that are photo-crosslinkable and thiol-containing so-called "mucoadhesives". By means of tensile force measurements immediately after bonding and after a time period of 24 h, values for the adh esive forces of the different materials are obtained. The commercial cyanoacrylate-based product as well as a photo-crosslinkable oligo ester shows the best adhesion results. In contrast, it was not possible to achieve the desired adhesive effects by applying catechol-containing polymers or other acrylic compounds. However, promising results are also obtained by thiol-containing polymers. After fine-tuning the latter, those polymers should have great potential as glues in specific applications.