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2013
Journal Article
Titel
The Non-Canonical IkB Kinases IKKe and TBK1 as Potential Targets for the Development of Novel Therapeutic Drugs
Abstract
IkB kinase epsilon (IKKe) and TANK-binding kinase 1 (TBK1) are two non-canonical IKKs which are involved in interferon regulatory factor (IRF) as well as nuclear factor kappaB (NF-kB) signaling cascades. Both kinases have already been linked to the pathophysiology of several diseases and therefore been suggested as potential promising targets for the development of therapeutic drugs. In this review, we summarize the roles of IKKe and TBK1 in different diseases and outline therapeutic options for modulation of these kinases.