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TTC concept: Non-oral routes and influence of local effects

: Escher, Sylvia E.


Toxicology letters 238 (2015), No.2, Supplement, pp.S7, Abstract CEC3-6
ISSN: 0378-4274
ISSN: 1879-3169
European Societies of Toxicology (EUROTOX Congress) <51, 2015, Porto>
Fraunhofer ITEM ()

The Threshold of Toxicological Concern (TTC) concept developed generic human threshold values by grouping compounds into three structural groups (Cramer et al., 1978). The present thresh-olds for non-genotoxic compounds were derived based on the 5thpercentile NOEL (no observed effect level) of a broad database containing in vivo studies with oral exposure (Munro et al., 1996).Route to route extrapolation is a difficult topic in human health risk assessment. Especially the evaluation of local effects, which frequently occur after inhalation but rarely after oral exposure is a difficult topic. It is therefore of interest to determine the conditions under which the TTC concept can be applied to assess toxicity for non-oral exposure i.e. inhalation or dermal. In this lecture recent results on TTC values for inhalation exposure will be introduced and strength and limitations discussed (Carthew et al., 2009; Escher et al., 2010, CEFIC LRI-B8). Further an overview on recent TTC approaches for dermal exposure will be given (