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IL16 - Improving the bioavailability of pharmacologically active substances in pharmaceutical and cosmetic formulations

: Storsberg, J.; Laughton, M.W.; Geyer, M.; Kumpugdee-Vollrath, M.; Schmidt, C.

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Asian journal of pharmaceutical sciences : AJPS 11 (2016), No.1, pp.33-34
ISSN: 1818-0876
ISSN: 2221-285X
Asian Federation for Pharmaceutical Sciences (AFPS Conference) <2015, Bangkok>
Journal Article, Conference Paper, Electronic Publication
Fraunhofer IAP ()

One and the same active ingredient can be used in different pharmaceutical applications to treat and cure diseases. Furthermore, the active ingredient can be used also in cosmetic formulations to care or aid the healing process. When applied topically via creams or lotions, they are referred as cosmeceuticals. In general, one aims to improve the bioavailability through tailored formulations and careful selection of components. An example is the use of latanoprost in ophthalmology for lowering the intraocular pressure in glaucoma patients with side effects including stimulated growth of eyelashes. Does this open up the possibility of using latanoprost for the local treatment for hair loss?
Latanoprost, when applied topically, shows a stimulating effect on the growth of eyelashes [1] and could serve as an agent against extensive hair loss. Hyaluronic acid is an active component which is selectively used against early skin aging [2]. The objective of this work was to establish surfactant stabilized cosmetic formulations and create galenicals based on latanoprost and creams based on hyaluronic acid.
Tococpherol was incorporated into lecithin based liposomes. Tocopherol served as a model substance for a lipophilic pharmacologically active ingredient. Using standard methods, such as thin-film hydration method, followed by and ultrasound-assisted formation of liposomes [3], we created particles of the desired size range. Hyaluronic acid was incorporated into various cream bases and viscosities were measured at varying temperatures. Latanoprost based foam preparations were established and investigated with regard to foam stability.
Aside from liposomes, charged polymers that are able to bind and/or “complex” a drug are suitable for improving drug delivery systems as well as for the generation of new pharmaceuticals and cosmeceuticals.