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Micelles from self-assembled double-hydrophilic PHEMA-glycopolymer-diblock copolymers as multivalent scaffolds for lectin binding

 
: Park, Hyunji; Walta, Stefan; Rosencrantz, R.R.; Körner, Andrea; Schulte, Christine; Elling, Lothar; Richtering, Walter; Böker, Alexander

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Polymer chemistry 7 (2016), No.4, pp.878-886
ISSN: 1759-9954
ISSN: 1759-9962
Deutsche Forschungsgemeinschaft DFG
SFB 985;
English
Journal Article
Fraunhofer IAP ()

Abstract
We introduce a novel double-hydrophilic hydroxyethylmethacrylate (HEMA) based diblock glycopolymer which self-assembles into homogeneous spherical micellar structures in water. The micellar structure renders surface-oriented N-acetylglucocosamine (GlcNAc) sugar moieties for strong multivalent glycan-mediated lectin binding. Structural analysis and lectin binding is performed by microscopy methods, dynamic light scattering (DLS) and two-focus fluorescence correlation spectroscopy (2fFCS), revealing a novel micellar type of multivalent sugar binding scaffold with high potential for biomedical applications.

: http://publica.fraunhofer.de/documents/N-382220.html