Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.

Micelles from self-assembled double-hydrophilic PHEMA-glycopolymer-diblock copolymers as multivalent scaffolds for lectin binding

: Park, Hyunji; Walta, Stefan; Rosencrantz, R.R.; Körner, Andrea; Schulte, Christine; Elling, Lothar; Richtering, Walter


Polymer chemistry 7 (2016), No.4, pp.878-886
ISSN: 1759-9954
ISSN: 1759-9962
Deutsche Forschungsgemeinschaft DFG
SFB 985;
Journal Article
Fraunhofer IAP ()

We introduce a novel double-hydrophilic hydroxyethylmethacrylate (HEMA) based diblock glycopolymer which self-assembles into homogeneous spherical micellar structures in water. The micellar structure renders surface-oriented N-acetylglucocosamine (GlcNAc) sugar moieties for strong multivalent glycan-mediated lectin binding. Structural analysis and lectin binding is performed by microscopy methods, dynamic light scattering (DLS) and two-focus fluorescence correlation spectroscopy (2fFCS), revealing a novel micellar type of multivalent sugar binding scaffold with high potential for biomedical applications.