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Evaluation of single-impact-induced cartilage degeneration by optical coherence tomography

 
: Bont, F. de; Brill, N.; Schmitt, R.; Tingart, M.; Rath, B.; Pufe, T.; Jahr, H.; Nebelung, S.

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BioMed research international (2015), Art.486794, 11 pp.
ISSN: 2314-6133
ISSN: 2314-6141
European Commission EC
FP7-HEALTH; 305815; D-BOARD
English
Journal Article, Electronic Publication
Fraunhofer IPT ()

Abstract
Posttraumatic osteoarthritis constitutes a major cause of disability in our increasingly elderly population. Unfortunately, current imaging modalities are too insensitive to detect early degenerative changes of this disease. Optical coherence tomography (OCT) is a promising nondestructive imaging technique that allows surface and subsurface imaging of cartilage, at near-histological resolution, and is principally applicable in vivo during arthroscopy. Thirty-four macroscopically normal human cartilage-bone samples obtained from total joint replacements were subjected to standardized single impacts in vitro (range: 0.25 J to 0.98 J). 3D OCT measurements of impact area and adjacent tissue were performed prior to impaction, directly after impaction, and 1, 4, and 8 days later. OCT images were assessed qualitatively (DJD classification) and quantitatively using established parameters (OII, Optical Irregularity Index; OHI, Optical Homogeneity Index; OAI, Optical Attenuation Index) and compared to corresponding histological sections. While OAI and OHI scores were not significantly changed in response to low-or moderate-impact energies, high-impact energies significantly increased mean DJD grades (histology and OCT) and OII scores. In conclusion, OCT-based parameterization and quantification are able to reliably detect loss of cartilage surface integrity after high-energy traumatic insults and hold potential to be used for clinical screening of early osteoarthritis.

: http://publica.fraunhofer.de/documents/N-369840.html