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Succinic acid production in fed-batch fermentation of Anaerobiospirillum succiniciproducens using glycerol as carbon source

: Bretz, Karlheinz


Chemical Engineering and Technology 38 (2015), No.9, pp.1659–1664
ISSN: 0930-7516
ISSN: 1521-4125
Journal Article
Fraunhofer UMSICHT Oberhausen ()
Anaerobiospirillum succiniciproducens; fermentation; Glyzerin; succinic acid

Considering glycerol as an inexpensive alternative carbon source, the optimal glycerol concentration for succinic acid production with Anaerobiospirillum succiniciproducens was identified in shake-flask trials. The addition of a defined amount of glucose improved the growth and succinic acid productivity significantly. In fed-batch processes with glycerol as sole substrate, a maximum succinic acid concentration and product substrate yield were obtained. The addition of glucose led to a 2.5-fold increased succinic acid concentration whereas the product substrate yield remained nearly constant.