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A CSPG4-specific immunotoxin kills rhabdomyosarcoma cells and binds to primary tumor tissues

 
: Brehm, H.; Niesen, J.; Mladenov, R.; Stein, C.; Pardo, A.; Fey, G.; Helfrich, W.; Fischer, R.; Gattenlöhner, S.; Barth, S.

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Cancer letters 352 (2014), No.2, pp.228-235
ISSN: 0304-3835
ISSN: 1872-7980
English
Journal Article
Fraunhofer IME ()

Abstract
The treatment of rhabdomyosarcoma (RMS) remains challenging, with metastatic and alveolar RMS offering a particularly poor prognosis. Therefore, the identification and evaluation of novel antigens, which are suitable targets for immunotherapy, is one attractive possibility to improve the treatment of this disease. Here we show that chondroitin sulfate proteoglycan 4 (CSPG4) is expressed on RMS cell lines and RMS patient material. We evaluated the immunotoxin (IT) αMCSP-ETA′, which specifically recognizes CSPG4 on the RMS cell lines RD, FL-OH1, TE-671 and Rh30. It is internalized rapidly, induces apoptosis and thus kills RMS cells selectively. We also demonstrate the specific binding of this IT to RMS primary tumor material from three different patients.

: http://publica.fraunhofer.de/documents/N-356179.html