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2D meets 4G: G-quadruplexes in RNA secondary structure prediction

: Lorenz, R.; Bernhart, S.H.; Qin, J.; Höner zu Siederdissen, C.; Tanzer, A.; Amman, F.; Hofacker, I.L.; Stadler, P.F.


IEEE ACM transactions on computational biology and bioinformatics 10 (2013), No.4, pp.832-844
ISSN: 1545-5963
ISSN: 1557-9964
Journal Article
Fraunhofer IZI ()

G-quadruplexes are abundant locally stable structural elements in nucleic acids. The combinatorial theory of RNA structures and the dynamic programming algorithms for RNA secondary structure prediction are extended here to incorporate G-quadruplexes using a simple but plausible energy model. With preliminary energy parameters, we find that the overwhelming majority of putative quadruplex-forming sequences in the human genome are likely to fold into canonical secondary structures instead. Stable G-quadruplexes are strongly enriched, however, in the 5ÊUTR of protein coding mRNAs.