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Cardiac function analysis in multi-cycle real-time MRI

 
: Chitiboi, T.; Hennemuth, A.; Tautz, L.; Hüllebrand, M.; Frahm, J.; Hahn, H.K.

International Society for Magnetic Resonance in Medicine -ISMRM-; European Society of Magnetic Resonance in Medicine and Biology -ESMRMB-:
Fashioning MR to improve global healthcare. ISMRM-ESMRBM Joint Annual Meeting 2014. Vol.5 : Milan, Italy, 10 - 16 May 2014
Red Hook, NY: Curran, 2015
ISBN: 978-1-63439-764-3
pp.3971
International Society for Magnetic Resonance in Medicine (ISMRM Annual Meeting) <22, 2014, Milan>
European Society for Magnetic Resonance in Medicine and Biology (ESMRMB Annual Meeting) <2014, Milan>
English
Conference Paper
Fraunhofer MEVIS ()

Abstract
A variety of different drugs block cardiac IKr-currents thus causing a serious side effect, the so called acquired Long-QT syndrome with a prolongation of cardiac repolarization (prolonged QT interval) and sudden cardiac death. Using Tissue Phase Mapping, we investigated the influence of IKr-blocking drug E4031 on global and segmental mechanical cardiac function in transgenic LQT type 1 rabbits (loss of IKs, with a particularly high susceptibility to IKr-blocking drugs) and wild-type littermate controls.

: http://publica.fraunhofer.de/documents/N-349696.html